Introduction: Cholelithiasis is a common surgical
problem. Laparoscopic cholecystectomy is the gold
standard of treatment for symptomatic cholelithiasis. It
requires creation of pneumoperitoneum which has some
physiological consequences like rise in liver function tests
indicating hepatic hypoperfusion and ischemia in patients
who were preoperatively normal.

Materials and methods: A prospective observational study
was conducted at Pokhara Academy of Health Sciences,
Pokhara from March to July 2022. One hundred patients
who underwent elective laparoscopic cholecystectomy
meeting inclusion criteria were enrolled. Data collection
was done using a structured porforma. Stastical analysis
was done SPSS version 21. Data were presented as mean
and standard deviation. Appropriate statistical tests were
applied and p value of <0.05 was considered significant.

Results: Out of hundred patients, twenty nine percent
were male and seventy- one percent were female with
mean age of 48.87 years. The post-operative day one
serum bilirubin ( mean 1.016) ,SGPT-Serum Glutamate
Pyruvate Trasaminase (mean 62.56) and SGOT-Serum
Glutamic Oxaloacetic transaminase (mean 61.74) were
increased as compaired to the pre-operative mean values
of 0.649, 34.96, and 35.46 respectively with p value of
0.000 where as mean of post-operative post-oprative day
seven values 0.644 , 32.21 , 32.98 were almost near to
pre-operative values. Mean of pre-operative(99.03 ) and
post-operative(95.75 ) ALP-Alkaline Phosphatase were
almost comparable.

Conclusion: There was a transient elevation in serum
bilirubin, Serum Glutamate Pyruvate Trasaminase, Serum
Glutamic Oxaloacetic Transaminase following laparoscopic
cholecystectomy due to carbondioxide pneumoperitonium
which normalized in the seventh postoperative day.


Keywords: Carbondioxide, Laparoscopic cholecystectomy, liver function tests, pneumoperitoneum