Introduction: Tracheal intubation is important
and frequently performed procedure for
anaesthesiologist. This study aimed to compare
the effect of esmolol and labetalol in preventing
hemodynamic response to laryngoscopy and

Materials and Methods: This is a prospective,
randomized and double blind study. Eighty patients
of either sex, aged between 18 to 60 years, American
Society of Anesthesiologist (ASA) category I and
II, scheduled for elective surgery requiring general
anesthesia are included in the study. They were
divided into two groups. Pre-oxygenation was
done. Then the study drugs were given according
to selected group according to lottery method. In
esmolol group, esmolol 0.5mg/kg diluted with 10
ml of normal saline was given 2 minutes prior to
intubation and in labetalol group, labetalol 0.1mg/
kg diluted with 10 ml of normal saline was given
5 min prior to intubation. Anesthesia was induced
with injection propofol. Laryngoscopy was done
after giving injection vecuronium and intubated
with appropriate sized cuffed tube. Heart rate,
systolic blood pressure, diastolic blood pressure
and mean arterial blood pressure were recorded at
post induction, before intubation and immediately
after intubation at 1, 3, and 5 minutes of tracheal
intubation. Any surgical stimulation was avoided
till 5 minutes.

Results: There was no significant difference
between two groups regarding the demographic
data. Heart Rate, Systolic Blood Pressure (SBP),
Diastolic Blood Pressure (DBP) and Mean Arterial
Pressure (MAP) at baseline, post induction and at
1 minute, 3 minutes and 5 minutes between two
groups were not significant statistically.

Conclusion: This study concluded that the
hemodynamic response to laryngoscopy and
intubation using esmolol and labetalol are similar.


Keywords: esmolol, labetalol, intubation, hemodynamic response