Introduction: Laparoscopic cholecystectomy
is considered as the gold standard treatment for
gallstone disease. There has remained a controversy
on use of peri operative prophylactic antibiotics
during laparoscopic cholecystectomy in reducing
perioperative prophylaxis surgical site infections.
Various studies has been done to evaluate whether
single dose/ three doses or multiple doses are needed
to decrease the incidence of surgical site infections.
The objective of this study was to identify the
incidence of postoperative surgical site infections
with three doses of perioperative antibiotics after
laparoscopic cholecystectomy.

Materials and Methods: This is a retrospective
observational study conducted at a private hospital
from November 2017 to March 2020. All the
patients received three doses of ceftriaxone 1 gram
within the first 24 hours of surgery. The incidence
of surgical site infection was noted.

Results: A total of 449 patients who fulfilled the
inclusion criteria were studied. The age ranged from
16 to 88 years. Male to female ratio was 1:4. Seven
cases (1.55%) developed postoperative surgical site

Conclusion: Three doses of perioperative antibiotics
are recommended in laparoscopic cholecystectomy
to prevent postoperative surgical site infections.


Keywords: Laparoscopic Cholecystectomy, Perioperative Antibiotics, Surgical site infections